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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TSC2
All Species:
9.09
Human Site:
S455
Identified Species:
20
UniProt:
P49815
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49815
NP_000539.2
1807
200608
S455
L
M
E
R
F
F
R
S
E
S
R
G
A
V
R
Chimpanzee
Pan troglodytes
XP_523477
1803
200189
S455
L
M
E
R
F
F
R
S
E
S
R
G
A
V
R
Rhesus Macaque
Macaca mulatta
XP_001083256
1807
200600
S455
L
M
E
R
F
F
R
S
E
S
R
G
A
V
R
Dog
Lupus familis
XP_852047
1813
201226
N455
L
M
E
R
F
F
R
N
E
S
R
S
A
V
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61037
1814
202053
N455
L
M
E
R
F
F
R
N
E
C
R
S
A
V
A
Rat
Rattus norvegicus
P49816
1809
201259
N455
L
M
E
R
F
F
R
N
E
C
R
S
A
V
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516748
947
107028
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695912
1128
123244
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524177
1847
204101
R456
Q
F
V
R
R
Y
Y
R
M
S
N
V
N
V
R
Honey Bee
Apis mellifera
XP_395739
1813
206229
M446
Q
F
K
L
A
N
L
M
E
R
Y
Y
K
I
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786931
1947
217345
R464
R
Y
F
R
S
E
S
R
T
V
I
R
E
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
97.9
91.2
N.A.
88.9
91
N.A.
44.1
N.A.
N.A.
35.8
N.A.
29.8
38.2
N.A.
31.1
Protein Similarity:
100
99
99
94.6
N.A.
92.2
93.9
N.A.
48.3
N.A.
N.A.
44.3
N.A.
49.7
58.6
N.A.
48.9
P-Site Identity:
100
100
100
86.6
N.A.
73.3
80
N.A.
0
N.A.
N.A.
0
N.A.
26.6
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
80
86.6
N.A.
0
N.A.
N.A.
0
N.A.
33.3
20
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
0
0
0
0
0
55
10
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
55
0
0
10
0
0
64
0
0
0
10
0
10
% E
% Phe:
0
19
10
0
55
55
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
28
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% I
% Lys:
0
0
10
0
0
0
0
0
0
0
0
0
10
0
0
% K
% Leu:
55
0
0
10
0
0
10
0
0
0
0
0
0
0
0
% L
% Met:
0
55
0
0
0
0
0
10
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
28
0
0
10
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
0
73
10
0
55
19
0
10
55
10
0
0
55
% R
% Ser:
0
0
0
0
10
0
10
28
0
46
0
28
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% T
% Val:
0
0
10
0
0
0
0
0
0
10
0
10
0
64
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
10
10
0
0
0
10
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _